Articles

Cossarizza, A.; Chang, H.; Radbruch, A.; Acs, A.; Adam, D.; Adam-Klages, S.; Agace, W. W.; Aghaeepour, N.; Akdis, M.; Allez, M.; et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur. J. Immunol. 2019, 49 (10), 1457-1973.

Cossarizza A, Chang H, Radbruch A, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019;49(10):1457-1973.

A. Cossarizza et al., “Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition),” Eur. J. Immunol., vol. 49, no. 10, pp. 1457-1973, Oct.. 2019.

Cossarizza A, Chang H, Radbruch A, Acs A, Adam D, Adam-Klages S, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct.;49(10):1457-973.

de Rond, L.; Libregts, S. F. W. M.; Rikkert, L. G.; Hau, C. M.; van der Pol, E.; Nieuwland, R.; van Leeuwen, T. G.; Coumans, F. A. W. Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry. J. Extracell. Vesicles 2019, 8, 1643671.

de Rond L, Libregts SFWM, Rikkert LG, et al. Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry. J Extracell Vesicles. 2019;8:1643671.

L. de Rond et al., “Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry,” J. Extracell. Vesicles, vol. 8, pp. 1643671, Jul. 2019.

de Rond L, Libregts SFWM, Rikkert LG, Hau CM, van der Pol E, Nieuwland R, et al. Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry. J Extracell Vesicles. 2019 Jul;8:1643671.

Pieragostino, D.; Lanuti, P.; Cicalini, I.; Cufaro, M. C.; Ciccocioppo, F.; Ronci, M.; Simeone, P.; Onofrj, M.; van der Pol, E.; Fontana, A.; et al. Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis. J. Proteomics 2019, 204, 103403.

Pieragostino D, Lanuti P, Cicalini I, et al. Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis. J Proteomics. 2019;204:103403.

D. Pieragostino et al., “Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis,” J. Proteomics, vol. 204, pp. 103403, Jul. 2019.

Pieragostino D, Lanuti P, Cicalini I, Cufaro MC, Ciccocioppo F, Ronci M, et al. Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis. J Proteomics. 2019 Jul;204:103403.

Geeurickx, E.; Tulkens, J.; Dhondt, B.; Van Deun, J.; Lippens, L.; Vergauwen, G.; Heyrman, E.; De Sutter, D.; Gevaert, K.; Impens, F.; et al. The generation and use of recombinant extracellular vesicles as biological reference material. Nat. Commun. 2019, 10 (1), 1-12.

Geeurickx E, Tulkens J, Dhondt B, et al. The generation and use of recombinant extracellular vesicles as biological reference material. Nat Commun. 2019;10(1):1-12.

E. Geeurickx et al., “The generation and use of recombinant extracellular vesicles as biological reference material,” Nat. Commun., vol. 10, no. 1, pp. 1-12, Jun. 2019.

Geeurickx E, Tulkens J, Dhondt B, Van Deun J, Lippens L, Vergauwen G, et al. The generation and use of recombinant extracellular vesicles as biological reference material. Nat Commun. 2019 Jun;10(1):1-2.

Rikkert, L. G.; van der Pol, E.; van Leeuwen, T. G.; Nieuwland, R.; Coumans, F. A. Centrifugation affects the purity of liquid biopsy-based tumor biomarkers. Cytom. Part A 2018, 93 (12), 1207-1212.

Rikkert LG, van der Pol E, van Leeuwen TG, Nieuwland R, Coumans FA. Centrifugation affects the purity of liquid biopsy-based tumor biomarkers. Cytom Part A. 2018;93(12):1207-1212.

L. G. Rikkert, E. van der Pol, T. G. van Leeuwen, R. Nieuwland, and F. A. Coumans, “Centrifugation affects the purity of liquid biopsy-based tumor biomarkers,” Cytom. Part A, vol. 93, no. 12, pp. 1207-1212, Dec. 2018.

Rikkert LG, van der Pol E, van Leeuwen TG, Nieuwland R, Coumans FA. Centrifugation affects the purity of liquid biopsy-based tumor biomarkers. Cytom Part A. 2018 Dec;93(12):1207-12.

Gąsecka, A.; van der Pol, E.; Nieuwland, R.; Stępień, E. Extracellular vesicles in post-infarct ventricular remodelling. Kardiol. Pol. 2018, 76 (1), 69-76.

Gąsecka A, van der Pol E, Nieuwland R, Stępień E. Extracellular vesicles in post-infarct ventricular remodelling. Kardiol Pol. 2018;76(1):69-76.

A. Gąsecka, E. van der Pol, R. Nieuwland, and E. Stępień, “Extracellular vesicles in post-infarct ventricular remodelling,” Kardiol. Pol., vol. 76, no. 1, pp. 69-76, Oct. 2018.

Gąsecka A, van der Pol E, Nieuwland R, Stępień E. Extracellular vesicles in post-infarct ventricular remodelling. Kardiol Pol. 2018 Oct;76(1):69-6.

de Rond, L.; Coumans, F. A. W.; Nieuwland, R.; van Leeuwen, T. G.; van der Pol, E. Deriving extracellular vesicle size from scatter intensities measured by flow cytometry. Curr. Protoc. Cytom. 2018, 86 (1), e43.

de Rond L, Coumans FAW, Nieuwland R, van Leeuwen TG, van der Pol E. Deriving extracellular vesicle size from scatter intensities measured by flow cytometry. Curr Protoc Cytom. 2018;86(1):e43.

L. de Rond, F. A. W. Coumans, R. Nieuwland, T. G. van Leeuwen, and E. van der Pol, “Deriving extracellular vesicle size from scatter intensities measured by flow cytometry,” Curr. Protoc. Cytom., vol. 86, no. 1, pp. e43, Aug. 2018.

de Rond L, Coumans FAW, Nieuwland R, van Leeuwen TG, van der Pol E. Deriving extracellular vesicle size from scatter intensities measured by flow cytometry. Curr Protoc Cytom. 2018 Aug;86(1):e43.

Varga, Z.; van der Pol, E.; Pálmai, M.; Garcia-Diez, R.; Gollwitzer, C.; Krumrey, M.; Fraikin, J.; Gasecka, A.; Hajji, N.; van Leeuwen, T. G.; et al. Hollow organosilica beads as reference particles for optical detection of extracellular vesicles. J. Thromb. Haemost. 2018, 16 (8), 1646-1655.

Varga Z, van der Pol E, Pálmai M, et al. Hollow organosilica beads as reference particles for optical detection of extracellular vesicles. J Thromb Haemost. 2018;16(8):1646-1655.

Z. Varga et al., “Hollow organosilica beads as reference particles for optical detection of extracellular vesicles,” J. Thromb. Haemost., vol. 16, no. 8, pp. 1646-1655, Jun. 2018.

Varga Z, van der Pol E, Pálmai M, Garcia-Diez R, Gollwitzer C, Krumrey M, et al. Hollow organosilica beads as reference particles for optical detection of extracellular vesicles. J Thromb Haemost. 2018 Jun;16(8):1646-55.

van der Pol, E.; de Rond, L.; Coumans, F. A. W.; Gool, E. L.; Böing, A. N.; Sturk, A.; Nieuwland, R.; van Leeuwen, T. G. Absolute sizing and label-free identification of extracellular vesicles by flow cytometry. Nanomed. Nanotechnol. 2018, 14 (3), 801-810.

van der Pol E, de Rond L, Coumans FAW, et al. Absolute sizing and label-free identification of extracellular vesicles by flow cytometry. Nanomed Nanotechnol. 2018;14(3):801-810.

E. van der Pol et al., “Absolute sizing and label-free identification of extracellular vesicles by flow cytometry,” Nanomed. Nanotechnol., vol. 14, no. 3, pp. 801-810, Apr. 2018.

van der Pol E, de Rond L, Coumans FAW, Gool EL, Böing AN, Sturk A, et al. Absolute sizing and label-free identification of extracellular vesicles by flow cytometry. Nanomed Nanotechnol. 2018 Apr;14(3):801-10.

de Rond, L.; van der Pol, E.; Hau, C. M.; Varga, Z.; Sturk, A.; van Leeuwen, T. G.; Nieuwland, R.; Coumans, F. A. W. Comparison of generic fluorescent markers for detection of extracellular vesicles by flow cytometry. Clin. Chem. 2018, 64 (4), 680-689.

de Rond L, van der Pol E, Hau CM, et al. Comparison of generic fluorescent markers for detection of extracellular vesicles by flow cytometry. Clin Chem. 2018;64(4):680-689.

L. de Rond et al., “Comparison of generic fluorescent markers for detection of extracellular vesicles by flow cytometry,” Clin. Chem., vol. 64, no. 4, pp. 680-689, Apr. 2018.

de Rond L, van der Pol E, Hau CM, Varga Z, Sturk A, van Leeuwen TG, et al. Comparison of generic fluorescent markers for detection of extracellular vesicles by flow cytometry. Clin Chem. 2018 Apr;64(4):680-9.

van der Pol, E.; Sturk, A.; van Leeuwen, T.; Nieuwland, R.; Coumans, F.; , S. W. G. Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation. J. Thromb. Haemost. 2018, 16 (6), 1236-1245.

van der Pol E, Sturk A, van Leeuwen T, Nieuwland R, Coumans F, SWG. Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation. J Thromb Haemost. 2018;16(6):1236-1245.

E. van der Pol, A. Sturk, T. van Leeuwen, R. Nieuwland, F. Coumans, and S. W. G. , “Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation,” J. Thromb. Haemost., vol. 16, no. 6, pp. 1236-1245, Mar. 2018.

van der Pol E, Sturk A, van Leeuwen T, Nieuwland R, Coumans F, SWG. Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation. J Thromb Haemost. 2018 Mar;16(6):1236-45.

van der Pol, E.; Harrison, P. From platelet dust to gold dust: physiological importance and detection of platelet microvesicles. Platelets 2017, 28 (3), 211-213.

van der Pol E, Harrison P. From platelet dust to gold dust: physiological importance and detection of platelet microvesicles. Platelets. 2017;28(3):211-213.

E. van der Pol, and P. Harrison, “From platelet dust to gold dust: physiological importance and detection of platelet microvesicles,” Platelets, vol. 28, no. 3, pp. 211-213, May. 2017.

van der Pol E, Harrison P. From platelet dust to gold dust: physiological importance and detection of platelet microvesicles. Platelets. 2017 May;28(3):211-3.

Coumans, F. A. W.; Brisson, A. R.; Buzas, E. I.; Dignat-George, F.; Drees, E. E. E.; El-Andaloussi, S.; Emanueli, C.; Gasecka, A.; Hendrix, A.; Hill, A. F.; et al. Methodological guidelines to study extracellular vesicles. Circ. Res. 2017, 120 (10), 1632-1648.

Coumans FAW, Brisson AR, Buzas EI, et al. Methodological guidelines to study extracellular vesicles. Circ Res. 2017;120(10):1632-1648.

F. A. W. Coumans et al., “Methodological guidelines to study extracellular vesicles,” Circ. Res., vol. 120, no. 10, pp. 1632-1648, May. 2017.

Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, et al. Methodological guidelines to study extracellular vesicles. Circ Res. 2017 May;120(10):1632-48.

Valkonen, S.; van der Pol, E.; Böing, A.; Yuana, Y.; Yliperttula, M.; Nieuwland, R.; Laitinen, S.; Siljander, P. R. M. Biological reference materials for extracellular vesicle studies. Eur. J. Pharm. Sci. 2017, 98, 4-16.

Valkonen S, van der Pol E, Böing A, et al. Biological reference materials for extracellular vesicle studies. Eur J Pharm Sci. 2017;98:4-16.

S. Valkonen et al., “Biological reference materials for extracellular vesicle studies,” Eur. J. Pharm. Sci., vol. 98, pp. 4-16, Feb. 2017.

Valkonen S, van der Pol E, Böing A, Yuana Y, Yliperttula M, Nieuwland R, et al. Biological reference materials for extracellular vesicle studies. Eur J Pharm Sci. 2017 Feb;98:4-6.

van der Pol, E.; Mudde, Y. D.; Coumans, F. A. W.; van Leeuwen, T. G.; Sturk, A.; Nieuwland, R. Wound scabs protect regenerating tissue against harmful ultraviolet radiation. Med. Hypotheses 2016, 96, 39-41.

van der Pol E, Mudde YD, Coumans FAW, van Leeuwen TG, Sturk A, Nieuwland R. Wound scabs protect regenerating tissue against harmful ultraviolet radiation. Med Hypotheses. 2016;96:39-41.

E. van der Pol, Y. D. Mudde, F. A. W. Coumans, T. G. van Leeuwen, A. Sturk, and R. Nieuwland, “Wound scabs protect regenerating tissue against harmful ultraviolet radiation,” Med. Hypotheses, vol. 96, pp. 39-41, Nov. 2016.

van der Pol E, Mudde YD, Coumans FAW, van Leeuwen TG, Sturk A, Nieuwland R. Wound scabs protect regenerating tissue against harmful ultraviolet radiation. Med Hypotheses. 2016 Nov;96:39-1.

van der Pol, E.; Böing, A. N.; Gool, E. L.; Nieuwland, R. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J. Thromb. Haemost. 2016, 14 (1), 48-56.

van der Pol E, Böing AN, Gool EL, Nieuwland R. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost. 2016;14(1):48-56.

E. van der Pol, A. N. Böing, E. L. Gool, and R. Nieuwland, “Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles,” J. Thromb. Haemost., vol. 14, no. 1, pp. 48-56, Nov. 2016.

van der Pol E, Böing AN, Gool EL, Nieuwland R. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost. 2016 Nov;14(1):48-6.

Cernohorsky, P.; Jansen, S. M.; de Bruin, D. M.; van der Pol, E.; Savci-Heijink, C. D.; Strackee, S. D.; Faber, D. J.; van Leeuwen, T. G. Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology. IEEE J. Sel. Top. Quant. 2016, 22 (3), 203-209.

Cernohorsky P, Jansen SM, de Bruin DM, et al. Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology. IEEE J Sel Top Quant. 2016;22(3):203-209.

P. Cernohorsky et al., “Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology,” IEEE J. Sel. Top. Quant., vol. 22, no. 3, pp. 203-209, May. 2016.

Cernohorsky P, Jansen SM, de Bruin DM, van der Pol E, Savci-Heijink CD, Strackee SD, et al. Quantitative assessment of optical properties in healthy cartilage and repair tissue by optical coherence tomography and histology. IEEE J Sel Top Quant. 2016 May;22(3):203-9.

Nicolet, A.; Meli, F.; van der Pol, E.; Yuana, Y.; Gollwitzer, C.; Krumrey, M.; Cizmar, P.; Buhr, E.; Pétry, J.; Sebaihi, N.; et al. Inter-laboratory comparison on the size and stability of monodisperse and bimodal synthetic reference particles for standardization of extracellular vesicle measurements. Meas. Sci. Technol. 2016, 27 (3), 035701.

Nicolet A, Meli F, van der Pol E, et al. Inter-laboratory comparison on the size and stability of monodisperse and bimodal synthetic reference particles for standardization of extracellular vesicle measurements. Meas Sci Technol. 2016;27(3):035701.

A. Nicolet et al., “Inter-laboratory comparison on the size and stability of monodisperse and bimodal synthetic reference particles for standardization of extracellular vesicle measurements,” Meas. Sci. Technol., vol. 27, no. 3, pp. 035701, Feb. 2016.

Nicolet A, Meli F, van der Pol E, Yuana Y, Gollwitzer C, Krumrey M, et al. Inter-laboratory comparison on the size and stability of monodisperse and bimodal synthetic reference particles for standardization of extracellular vesicle measurements. Meas Sci Technol. 2016 Feb;27(3):035701.

Yuana, Y.; Böing, A. N.; Grootemaat, A. E.; van der Pol, E.; Hau, C. M.; Cizmar, P.; Buhr, E.; Sturk, A.; Nieuwland, R. Handling and storage of human body fluids for analysis of extracellular vesicles. J. Extracell. Vesicles 2015, 4, 29260.

Yuana Y, Böing AN, Grootemaat AE, et al. Handling and storage of human body fluids for analysis of extracellular vesicles. J Extracell Vesicles. 2015;4:29260.

Y. Yuana et al., “Handling and storage of human body fluids for analysis of extracellular vesicles,” J. Extracell. Vesicles, vol. 4, pp. 29260, Nov. 2015.

Yuana Y, Böing AN, Grootemaat AE, van der Pol E, Hau CM, Cizmar P, et al. Handling and storage of human body fluids for analysis of extracellular vesicles. J Extracell Vesicles. 2015 Nov;4:29260.

Coumans, F. A. W.; van der Pol, E.; Böing, A. N.; Hajji, N.; Sturk, G.; van Leeuwen, T. G.; Nieuwland, R. Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing. J. Extracell. Vesicles 2014, 3, 25922.

Coumans FAW, van der Pol E, Böing AN, et al. Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing. J Extracell Vesicles. 2014;3:25922.

F. A. W. Coumans et al., “Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing,” J. Extracell. Vesicles, vol. 3, pp. 25922, Dec. 2014.

Coumans FAW, van der Pol E, Böing AN, Hajji N, Sturk G, van Leeuwen TG, et al. Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing. J Extracell Vesicles. 2014 Dec;3:25922.

van der Pol, E.; Coumans, F. A. W.; Sturk, A.; Nieuwland, R.; van Leeuwen, T. G. Refractive index determination of nanoparticles in suspension using nanoparticle tracking analysis. Nano Lett. 2014, 14 (11), 6195-6201.

van der Pol E, Coumans FAW, Sturk A, Nieuwland R, van Leeuwen TG. Refractive index determination of nanoparticles in suspension using nanoparticle tracking analysis. Nano Lett. 2014;14(11):6195-6201.

E. van der Pol, F. A. W. Coumans, A. Sturk, R. Nieuwland, and T. G. van Leeuwen, “Refractive index determination of nanoparticles in suspension using nanoparticle tracking analysis,” Nano Lett., vol. 14, no. 11, pp. 6195-6201, Sep. 2014.

van der Pol E, Coumans FAW, Sturk A, Nieuwland R, van Leeuwen TG. Refractive index determination of nanoparticles in suspension using nanoparticle tracking analysis. Nano Lett. 2014 Sep;14(11):6195-201.

Böing, A. N.; van der Pol, E.; Grootemaat, A. E.; Coumans, F. A. W.; Sturk, A.; Nieuwland, R. Single-step isolation of extracellular vesicles by size-exclusion chromatography. J. Extracell. Vesicles 2014, 3, 23430.

Böing AN, van der Pol E, Grootemaat AE, Coumans FAW, Sturk A, Nieuwland R. Single-step isolation of extracellular vesicles by size-exclusion chromatography. J Extracell Vesicles. 2014;3:23430.

A. N. Böing, E. van der Pol, A. E. Grootemaat, F. A. W. Coumans, A. Sturk, and R. Nieuwland, “Single-step isolation of extracellular vesicles by size-exclusion chromatography,” J. Extracell. Vesicles, vol. 3, pp. 23430, Sep. 2014.

Böing AN, van der Pol E, Grootemaat AE, Coumans FAW, Sturk A, Nieuwland R. Single-step isolation of extracellular vesicles by size-exclusion chromatography. J Extracell Vesicles. 2014 Sep;3:23430.

van der Pol, E.; Coumans, F. A. W.; Grootemaat, A. E.; Gardiner, C.; Sargent, I. L.; Harrison, P.; Sturk, A.; van Leeuwen, T. G.; Nieuwland, R. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J. Thromb. Haemost. 2014, 12 (7), 1182-1192.

van der Pol E, Coumans FAW, Grootemaat AE, et al. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost. 2014;12(7):1182-1192.

E. van der Pol et al., “Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing,” J. Thromb. Haemost., vol. 12, no. 7, pp. 1182-1192, May. 2014.

van der Pol E, Coumans FAW, Grootemaat AE, Gardiner C, Sargent IL, Harrison P, et al. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost. 2014 May;12(7):1182-.

Varga, Z.; Yuana, Y.; Grootemaat, A. E.; van der Pol, E.; Gollwitzer, C.; Krumrey, M.; Nieuwland, R. Towards traceable size determination of extracellular vesicles. J. Extracell. Vesicles 2014, 3, 23298.

Varga Z, Yuana Y, Grootemaat AE, et al. Towards traceable size determination of extracellular vesicles. J Extracell Vesicles. 2014;3:23298.

Z. Varga et al., “Towards traceable size determination of extracellular vesicles,” J. Extracell. Vesicles, vol. 3, pp. 23298, Feb. 2014.

Varga Z, Yuana Y, Grootemaat AE, van der Pol E, Gollwitzer C, Krumrey M, et al. Towards traceable size determination of extracellular vesicles. J Extracell Vesicles. 2014 Feb;3:23298.

Nguyen, V. D.; Faber, D. J.; van der Pol, E.; van Leeuwen, T. G.; Kalkman, J. Dependent and multiple scattering in transmission and backscattering optical coherence tomography. Opt. Express 2013, 21 (24), 29145-29156.

Nguyen VD, Faber DJ, van der Pol E, van Leeuwen TG, Kalkman J. Dependent and multiple scattering in transmission and backscattering optical coherence tomography. Opt Express. 2013;21(24):29145-29156.

V. D. Nguyen, D. J. Faber, E. van der Pol, T. G. van Leeuwen, and J. Kalkman, “Dependent and multiple scattering in transmission and backscattering optical coherence tomography,” Opt. Express, vol. 21, no. 24, pp. 29145-29156, Nov. 2013.

Nguyen VD, Faber DJ, van der Pol E, van Leeuwen TG, Kalkman J. Dependent and multiple scattering in transmission and backscattering optical coherence tomography. Opt Express. 2013 Nov;21(24):29145-56.